Diseases associated with TTN include Myopathy, Myofibrillar, 9, With Early Respiratory Failure and Tibial Muscular Dystrophy, Tardive.Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Striated Muscle Contraction.Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. TTN (Titin) is a Protein Coding gene. The name titin is derived from the Greek Titan (a giant deity, anything of great size). Die maken samen met de filamenten van actine en myosine deel uit van de sarcomeer, die ervoor zorgt dat spieren kunnen samentrekken. Zwei Jahre später identifizierten Kuan Wang und Mitarbeiter auf einem Elektrophoresegel eine Dublettenbande, die einem hochmolekularen, elastischen Protein entsprach, das sie Titin nannten.[5][6]. Details. Franziska Rudolph, Judith Hüttemeister, Katharina da Silva Lopes, René Jüttner, Lily Yu, Nora Bergmann, Dhana Friedrich, Stephan Preibisch, Eva Wagner, Stephan E Lehnart, Carol C Gregorio, Michael Gotthardt: Diese Seite wurde zuletzt am 18. Siegfried Labeit isolierte 1990 einen partiellen cDNA-Klon von Titin. Its full chemical name is 189,819 letters long and, depending on how you define a “word” is the longest word in the English language. titin ( uncountable ) ( biochemistry) A protein important in the contraction of striated muscle tissues. Below is a list of characters that appear originally in the Attack on Titan manga. quotations . Privacy policy. The initial part of it is pronounced almost like Titan, but please do not confuse it with Titan. It has a theoretical instability index (II) of 39.69, indicating that it would be stable in a test tube. Titin is believed to play an integral part in the contraction of striated muscle tissues. It’s Titin I’m talking about. No, I’m not talking about the fictional character Tintin. [4] Es stellte sich heraus, dass dieses Protein größer ist als alle bislang bekannten Muskeleiweiße. Tintin seems to be physically quite strong as he sometimes defeats criminals without much difficulty with punches and onc… Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE. Tintin (/ ˈtɪntɪn /; French: [tɛ̃tɛ̃]) is the titular protagonist of The Adventures of Tintin, the comics series by Belgian cartoonist Hergé. Außerdem ist das Titin verantwortlich für die Ruhespannung des Muskels und wird daher auch oft in Diskussionen um Sinn oder Unsinn des Dehnens angeführt. When ever i search this up, this is what i see "Methionylthreonylthreonylglutaminylarginyl...isoleucine" NEVER the full word. See also the list of minor characters from the Attack on Titan Character Encyclopedia. Titin / ˈ t aɪ t ɪ n /, juga dikenal sebagai konektin, adalah suatu protein yang pada manusia, dikodekan oleh gen TTN. Titin, which has Ig-folds itself, binds directly to the Ig-fold domain of both A- and B-type lamins in vitro, with a slight preference for lamin A (Zastrow et al., 2006).Titin binding was mildly but selectively sensitive to specific laminopathy-causing missense mutations in the Ig-fold domain of lamin A, suggesting these mutations might perturb lamin–titin connections. About SNPedia Your browser does not support JavaScript. Labeit und Kollegen bestimmten 2001 die vollständige Sequenz des menschlichen Titin-Gens. Titin, also known as connectin (UniProt name: Q10466_HUMAN; accession number: Q10466), is a protein that is important in the contraction of striated muscle tissues. Huygens was inspired by Galileo's discovery of Jupiter's four largest moons in 1610 and his improvements in telescope technology. Estes módulos repítense centos de veces para formar a proteína completa. Das humane Titin besteht aus ca. Champion of the Doubles Hand-pelota tournaments of 1994, 2000, 2004 and 2012. 34.000 Aminosäuren und hat 320 Proteindomänen und ist damit das größte bekannte menschliche Protein. Titian, Italian in full Tiziano Vecellio or Tiziano Vecelli, (born 1488/90, Pieve di Cadore, Republic of Venice [Italy]—died August 27, 1576, Venice), the greatest Italian Renaissance painter of the Venetian school.He was recognized early in his own lifetime as a supremely talented painter, and his reputation has in the intervening centuries never suffered a decline. Berechnungen ergeben, dass es bei einem erwachsenen Mann 400 Gramm des Körpergewichts ausmacht. The name of the protein titn is 189,819 letters long and the longest one in English. In order of first appearance, methionyl (which appears 337 times, including as the first component); threonyl (which appears 2083 times, initially as the second and third component); glutaminyl (which appears 724 times, initially as the fourth component); alanyl (which appears 1632 times, initially as the fifth component) Die Geschichte von Titin begann Ende der siebziger Jahre. Der Aufbau des Titin unterscheidet sich in Skelett- und Herzmuskulatur, womit die geringere Dehnbarkeit des kardialen Sarkomers erklärt werden kann. Tintin made his first appearance in Tintin in the Land of the Soviets (1929–1930) as a journalist reporting on the Bolsheviks of Soviet Russia with his loyal dog Snowy and soon evolved into an investigative reporter and crime-buster whose curiosity draws him into the dangerous circles of drug-traffickers and mercenaries. A titina, tamén chamada conectina, é unha proteína do tecido muscular, que nos humanos está codificada polo xene TTN do cromosoma 2. Titin, also known as connectin, (UniProt name: Q10466_HUMAN; accession number: Q10466) is a protein that is important in the contraction of striated muscle tissues. Snowy (French: Milou) is Tintin's Wire Fox Terrier and a protagonist of the series. Die Anzahl der PEVK-Motive im Titin-Gen scheint im Laufe der Evolution zugenommen zu haben, wodurch sich offenbar die genomische Region, die für die Eigenschaften der Titin-Feder verantwortlich ist, verändert hat.[7]. Titin's shortened species name of "Glu'taminyl'serxiso'leucinian" is the final 34 letters of the word, albeit similarly separated by apostrophes and with the final letter also replaced by the "-ian" suffix. Christiaan, with the help of his elder brother Constantijn Huygens, Jr., began building telescopes around 1650 and discovered the first observed moon orbiting Saturn … Titin (auch Connectin) ist ein etwa 3,6 Megadalton schweres, elastisches Protein, welches sich zu Filamenten (Proteinfäden) zusammensetzt. This page was last edited on 5 May 2016, at 10:36. Während des größten Teils des vergangenen Jahrhunderts war die Existenz von Titin, dem größten Protein im menschlichen Körper, unbekannt, obwohl es nach heutigen Erkenntnissen das dritthäufigste Muskeleiweiß nach Myosin und Aktin ist. Titin is the largest protein molecule ever discovered. Your task is to output this entire name! Augusto Ibáñez Sacristán is a Basque pelota forward player. Comprising 189819 characters, the full name of titin would take about 3.5 hours to pronounce. This … An der Muskelkontraktion ist das Titinfilament nicht beteiligt, es sorgt für die Elastizität und Stabilität des Muskels und bestimmt die Kontraktionsgeschwindigkeit in wesentlichem Maße mit. The molecular weight of the mature protein is approximately 2,993,451.39 Da, and it has a theoretical pI of 6.01[2] The protein's empirical chemical formula is C132983H211861N36149O40883S693. Das Titinfilament ist gemeinsam mit dem Aktinfilament über Alpha-Aktinin mit der Z-Scheibe mechanisch verbunden. Vorhandene Strukturdaten: 1bpv, 1g1c, 1h8b, 1nct, 1ncu, 1tit, 1tiu, 1tki, 1tnm, 1tnn, 1waa, 1ya5, 2a38, 2bk8, 2f8v, 2ill, 2nzi, 3lpw, 3puc, 3q5o, 3qp3, 3knb. The full-length scientific name of this protein molecule contains 189,819 characters and is considered (by some) as th… Stefan Silbernagel, Agamemnon Despopoulos: K. Maruyama, S. Matsubara, R. Natori, Y. Nonomura, S. Kimura: M. L. Bang, T. Centner, F. Fornoff, A. J. Geach, M. Gotthardt, M. McNabb, C. C. Witt, D. Labeit, C. C. Gregorio, H. Granzier, S. Labeit: https://de.wikipedia.org/w/index.php?title=Titin&oldid=209926512, „Creative Commons Attribution/Share Alike“. The name titin is derived from the Greek Titan (a giant deity, anything of great size). Diese Bindung ist relativ schwach und gut regulierbar, eine notwendige Voraussetzung für den ungehinderten Kontraktionsvorgang. Additional recommended knowledge Essential Laboratory Skills Guide Wikipedia titin The Adventures of Tintin (film) - Wikipedia . 1995 bestimmten Labeit und Bernhard Kolmerer die cDNA-Sequenz des menschlichen kardialen Titins und zeigten, dass in verschiedenen Muskeln Isoformen des Protein existieren, die sich erheblich in ihrer Größe unterscheiden. epimysium, fascicle, perimysium, endomysium, muscle fiber (intrafusal, extrafusal), myofibril. Titin là một protein khổng lồ, lớn hơn 1 mm chiều dài, có chức năng như một phân tử lò xo chịu trách nhiệm về tính đàn hồi thụ động của cơ bắp. It is not included in the dictionary – few lexicographers accept chemical formulae as words. Titin, also known as connectin[1] (UniProt name: Q10466_HUMAN; accession number: Q10466), is a protein that is important in the contraction of striated muscle tissues. The full chemical name, containing 189,819 letters, is sometimes stated to be the longest word in the English language. Titan was discovered on March 25, 1655, by the Dutch astronomer Christiaan Huygens. From the chemicals which constitute the protein. The identity of the longest word in English depends upon the definition of what constitutes a word in the English language, as well as how length should be compared. Titin (Human, Homo sapiens) is found to have a chain of 34,350 amino acids with its IUPAC chemical name* having 241,578 letters: "Methionylthreonylthreonylglutaminylalanylprolylthreonyl...isoleucylarginylserylisoleucine". Es dauerte mehrere Jahrzehnte, bis das Vorhandensein von Titin im Sarkomer allgemein akzeptiert wurde. Từ dài nhất trong tiếng Anh được xác định phụ thuộc vào định nghĩa của một từ trong tiếng Anh, cũng như là cách so sánh độ dài các từ như thế nào.. Các từ có thể có từ nguồn gốc của tiếng Anh hoặc được hình thành bằng cách đặt ra hay chắp dính. Das menschliche Gen, das für Titin kodiert, befindet sich auf dem langen Arm von Chromosom 2 und enthält 363 Exons, die zusammen für 38.138 Reste (4200 kDa) kodieren. Read what you need to know about our industry portal chemeurope.com. Titin (auch Connectin) ist ein etwa 3,6 Megadalton schweres, elastisches Protein, welches sich zu Filamenten (Proteinfäden) zusammensetzt. Anschaulich beschrieben wirkt es wie ein großes Gummiband in unseren Muskeln. The full name can be found here: Pastebin Titin connects the Z line to the M line in the sarcomere. Chemical Name of Titin–The Longest Word ylglutaminylalanylarginylthreonylthreonylglutaminylvalylglutaminylglutaminylphenylalanylserylglutamin ylvalyltryptophyllysylprolylphenylalanylprolylglutaminylserylthreonylvalylarginylphenylalanylprolylglycy Das humane Titin besteht aus ca. Noun. Titin is a protein found in muscle tissue. It is a pretty big protein, and its full chemical name is giant as well. The chemical formula is: C 132983 H 211861 N 36149 O 40883 S 693. 34.000 Aminosäuren[1] und hat 320 Proteindomänen und ist damit das größte bekannte menschliche Protein. 1977 isolierten Koscak Maruyama und Mitarbeiter ein elastisches Protein aus Muskelfasern, das sie Connectin nannten. The bond between the two is significantly strong, as they have saved each other's lives numerous times throughout the series. When we are in Snowy's mind, it generally consists of a debate between a "good" and "bad" version of Snowy's conscience. English Etymology. All 189,819 letters of the chemical name of titin, the largest known protein. He is a reporter and adventurer who travels around the world with his dog Snowy. To use all the functions on Chemie.DE please activate JavaScript. So besitzt die kardiale Titinisoform eine Masse von ungefähr 3 MDa, während das Titin des Musculussoleus ungefähr 3,7 MDa aufweist. Find out how LUMITOS supports you with online marketing. Im Bereich des I-Bandes ist das lange Polypeptid elastisch und kann gedehnt werden. Titin's Chemical Name (Full Form) of 189,819 is shown Below :-. To use all functions of this page, please activate cookies in your browser. sarcomere (a, i, and h bands; z and m lines), myofilaments (thin filament/actin, thick filament/myosin, elastic filament/titin, nebulin), tropomyosin, troponin (T, C, I), costamere (dystrophin, α,β-dystrobrevin, syncoilin, synemin/desmuslin, dysbindin, sarcoglycan, dystroglycan, sarcospan), desmin, neuromuscular junction, motor unit, muscle spindle, excitation-contraction coupling, sliding filament mechanism. Tintin has fair skin and ginger hair swept upwards. [2] Es ist ein Teil des Sarkomers, der kleinsten funktionellen Einheit in der quergestreiften Muskulatur. Find out more about the company LUMITOS and our team. Titin is the largest protein yet discovered. Recommended Name: Titin Size: 34350 amino acids; 3816030 Da Cofactor: Magnesium Subunit: Interacts with MYOM1, MYOM2, tropomyosin and myosin. The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to disappear after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes).[3]. [4] [5] Titin adalah sebuah protein raksasa, panjangnya lebih dari 1 µm , [6] fungsinya yaitu sebagai molekul pegas yang bertanggung jawab atas elastisitas pasif otot . Zusätzlich bindet es im Bereich der Z-Scheibe an Telethonin (T-Cap). Ngoài ra, … With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter. Die Theorien zur Muskelkontraktion basierten auf den damals bekannten Molekülen, insbesondere auf Aktin und Myosin. Bách khoa toàn thư mở Wikipedia Titin / ˈtaɪtɪn /, còn được gọi là connectin, là một protein được TTN gen mã hóa ở con người. As the largest known protein, titin has the longest full chemical name. Titin ( / ˈ t aɪ t ɪ n /), also known as connectin, is a protein that in humans is encoded by the TTN gene. In all of his appearances, he wears a blue shirt with a white collar, brown pants, white socks, shoes, and frequently wears a beige trench coat. Paradoxerweise wurde es gerade auf Grund seiner Größe lange Zeit übersehen: Das Protein hat in den üblichen Gel-Elektrophoresen eine zu geringe Mobilität und kann nicht nachgewiesen werden; erst wenn man extrem dünne Gele verwendet, wird es auf dem Gel sichtbar. © 1997-2021 LUMITOS AG, All rights reserved, https://www.chemeurope.com/en/encyclopedia/Titin.html, Your browser is not current. Titin is the largest known protein, consisting of 26,926 amino acids. [1] [2] Titin is a giant protein that functions as a molecular spring which is responsible for the passive elasticity of muscle.It is composed of 244 individually folded protein domains connected by unstructured peptide sequences. März 2021 um 15:25 Uhr bearbeitet. That stands for a scientific name for Trypthophan synthetase And is 1909 letters However, there is a word that stands for deoxyribonucleic acid (DNA) and is 207000 letters it was never printed. Innerhalb des Gens befindet sich eine große Anzahl von PEVK-Exons (Prolin-Glutamat-Valin-Lysin – reichlich Exons) mit einer Länge von 84 bis 99 Nukleotiden, die für konservierte 28- bis 33 Restmotive kodieren, die Struktureinheiten der Titin-PEVK-Feder darstellen können. Im Bereich des A-Bandes ist es mit seinem steifen Carboxylende mit der M-Scheibe verbunden.[3]. Snowy seldom "speaks", but is instead seen thinking. Soon you’ll see why it is the largest…Titin is the short name for an extremely massive protein molecule. The protein limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. Titine of connectine is een proteïne dat vezelachtige structuren (microfilamenten) vormt. Die Aufgabe des Titins im Sarkomer ist, die Myosinköpfe zwischen den Aktinfilamenten zu zentrieren und den kontraktilen Apparat nach der Dehnung zurückzustellen. Dieser enorme Größenunterschied basiert auf unterschiedlich langen I-Band-Titin-Bereichen dieser Muskeln. Titin, also known as connectin, (UniProt name: Q10466_HUMAN; accession number: Q10466) is a protein that is important in the contraction of striated muscle tissues. Below is the full 189,819-lettered word for 'titin': ... ©2021 Hearst UK is the trading name of the National Magazine Company Ltd, 30 Panton Street, Leicester Square, London, SW1Y 4AJ.